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Hjernen og ryggmargen mangler et signal og skrur opp sin sensitivitet. Da vil guy kunne plukke opp mye annet støy som kan oppfattes som smerter. Etter hvert vil kroppen kunne tilpasse seg situasjonen og skru ned sensitiviteten igjen, forklarer Tjølsen.Nevropatisk smerte er definert som smerte som oppstår som en direkte følge av skade eller sykd
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